Nocturnal and spontaneous erections will usually stop in under a week. All the information you need to be informed on DIY Hormone Replacement Therapy 24h after the . Estradiol gel is found in individual 1 gram sachets or multiple dose tubes (30 g to 80 g). 1999). Maximum single dose patch available is 0.1 mg . Estradiol valerate 5-20mg IM q2 weeks . Undiagnosed abnormal genital bleeding. The two main forms are estradiol valerate and estradiol cypionate (also known as Depo-Estradiol). I use a 23g x 1.5 inch needle. The dose of estradiol valerate tablets starts at 2-4 mg daily, increasing up to 8 mg. Tablets can be given in divided doses if nausea occurs at higher doses. The usual dosage is 10 to 20 mg DELESTROGEN (estradiol valerate) every four weeks. One possible regimen: start with a moderate estrogen dose (e.g., estradiol, 2 mg BID); one month later, advance to a higher dose (e.g., estradiol, 6-8 mg qD, divided doses); one month later, add spironolactone, 100 mg . Adjust the dose as needed (packets available as estradiol 0.25, 0.5, 0.75, 1, and 1.25 mg) Maximum dose: 1.25 mg/day. Known, suspected, or history of cancer of the breast. Ask him for estradiol cypionate instead of estradiol valerate. Libido, as it is known to people with testosterone, will drop, and later . Healthy transdermal estradiol dosage for MtF with fast metaboilsm is not real at all.I don't know whether I have a fast metabolism. You may also notice that most of the hormone levels are the same range for both males and postmenopausal women. Known or suspected estrogen-dependent neoplasia. 5 mg/ml, 1 ml twice a week (say, Sunday morning and Wednesday evening). She was losing bone mass at the rate of 5% per year while taking androgen-blockers without also taking estrogen (Hierl et al. An LH that is higher than FSH is one indication of PCOS. Estradiol Valerate Injection should not be used in women with any of the following conditions: 1. Male-to-female (MTF) hormone therapy, or estrogen hormone therapy, can cause a person to experience physical, emotional, sexual, and reproductive changes. recommended by the Transgender Health Program. Your dosage level seems normal to me. Estradiol valerate 1 mg is equal to estradiol 0.76 mg. Estradiol valerate has been used to create a novel four-phasic oral contraceptive pill effective in both pregnancy prevention and the treatment of heavy menstrual bleeding. Gels roughly correspond to the daily doses found in the 50 mcg and 100 mcg patches. The usual dosage is 30 mg or more administered every one or two weeks. What Is Delestrogen? Because of these risks, estrogens with or without progestins should be prescribed at . aNot available in the USA. Anti-androgen: Spironolactone (Aldactone), 100 - 300 mg PO qD (divided doses). 2. However, we observe that in some patients the EC seems to have about 2-3.5 times the effective bioavailability by weight, and requires a proportionately smaller dose (despite having identical theoretical . Estradiol valerate, 20 mg IM q two weeks. [22] Patches or implants are preferred for transwomen over 40 years of age (although they can be used in younger people) to minimise the risk of venous thromboembolism. Transdermal Metered-Dose Pump. I have some friends who need to inject more than double my dosage to get the same estradiol level. 1. If you have been prescribed a dose that is quite a bit higher or . Estradiol: 2-4 mg daily: Parental (subcutaneous, intramuscular) Estradiol valerate: 5-30 mg every 2 weeks: Transdermal: Estradiol: 0.1-0.4 mg twice weekly: Anti-androgens: Progesterone: 20-60 mg PO daily: Medroxyprogesterone acetate: 150 mg IM every 3 months: GnRH agonist (leuprolide) 3.75-7.5 mg IM monthly: Histrelin implant: 50 mg . A "normal" patch dose is 100 to 400mcg per day, and a low dose estrogen patch would be around 50mcg per day. Initial dose: Apply 0.25 mg topically once a day to the skin of either the right or left upper thigh. Blood test at 15 weeks ESTRADIOL TOTAL >1000 pg/ml (off the charts) I also take micronized progesterone oral 200 MG per day and 25mg spiro twice a day. In a German case study, bone loss was reversed in an MTF woman by adding 2 mg of oral estradiol valerate daily to the 100 mg of cyproterone daily she was already taking. The most common doses are 10 mg or 0.5 ml per week of the estradiol valerate (usually a 20 mg/ml concentration which comes in a 5 ml vial) and 2.5 mg or 0.5 ml per week of the estradiol cypionate 5 mg/ml concentration (also comes in a 5 ml vial). b based on sublingual estradiol having ~2- to 5-fold greater bioavailability than oral estradiol per studies ( wiki; sam s., 2021 ). A prospective study of transgender women taking 4mg/day divided dose oral estradiol or 100mcg transdermal estradiol, plus 100-200mg/day divided dose spironolactone found that all women achieved physiologic estradiol levels, though only 2/3 of the women achieved female range testosterone levels. Some transgender people transition. Including a testosterone blocker: About 3 days. 3. LH LEVELS . Today I will inject my 21st dosage of Estradiol Valerate. [12] In the past, it was used at even higher doses of 10 to 40 every 1 to 4 weeks for estrogen replacement. . 2. Bone Health in MTF Studies give mixed results - Increase in osteopenia and osteoporosis compared to natal men, but generally preserved compared to natal women Periods of unopposed androgen blockade may have impacted Most male-to-female transsexual patients essentially are starting from the postmenopausal/male range. It varies per person, depending on how your body reacts to the medication. 4. Find patient medical information for estradiol valerate intramuscular on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. oral estradiol 1.5 mg is equivalent to about 2 mg oral estradiol valerate ( wiki ). combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Estradiol valerate is designated chemically as estra-1,3,5(10)-triene . Monitoring for transgender women (MTF) on hormone therapy: 5. [36] Known, suspected, or history of cancer of the . A 50 mcg patch is equivalent to 0.05 mg, and 100 mcg patch is equivalent to . Estradiol Valerate: Usually injected intramuscularly, a "normal" dose of estradiol valerate would be between 20 and 40mg every two weeks. The dose of estradiol valerate tablets starts at 2-4 mg daily, increasing up to 8 mg. Tablets can be given in divided doses if nausea occurs at higher doses. Undiagnosed abnormal genital bleeding. Estradiol valerate by intramuscular injection is usually used at a dosage of 10 to 20 mg every 4 weeks in the treatment of menopausal symptoms and hypoestrogenism due to hypogonadism, castration, or primary ovarian failure in women. Drug Formulation Goserelin 3.6mg injection & 10.8mg injection Leuprorelin 3.75mg and 11.25mg injection Estradiol Valerate (Oestradiol) 1mg & 2mg tablets Estradiol patches Twice weekly matrix patches releasing approximately 50, 75 & 100 microgram/24 hours Estradiol gel 0.1% gel (Sandrena) Finasteride 5mg tablets Initial dose (Elestrin): Apply 1 pump (0.52 mg) topically to upper arm once a day; dose . Your health provider may start you on a lower dose if you have chronic health problems, are at risk for specific side effects, or have had your testicles removed. of side effects. The use of unopposed estrogens in women who have a uterus is associated with an increased risk of endometrial cancer. A microdose would be injecting less than 20mg every two weeks. For treatment of advanced androgen-dependent carcinoma of the prostate, for palliation only. . Transdermal route: such as estradiol patch 0,1-0,4mg/24h once or twice a week or estradiol hemihydrate gel 0,5-1,5mg/dose Conjugated estrogens and ethinyl estradiol are not recommended due to the increased risk of cardiovascular pathologies such as deep vein thrombosis (DVT) and linked cardiovascular events. [9] Some physicians, switching their patients from estradiol valerate injection to estradiol cypionate, are assuming the dosage is identical. c much lower doses of transdermal estradiol can be used in the case of genital application relative to conventional skin sites ( . Estradiol Valerate Injection should not be used in women with any of the following conditions: 1. Delestrogen (estradiol valerate injection) is a form of estrogen, a female hormone, used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation.Delestrogen is also used to treat a lack of estrogen that is caused by ovarian failure or a condition called hypogonadism.Some forms of estradiol injection are used in men to treat the . HOW SUPPLIED DELESTROGEN (estradiol valerate injection, USP) Multiple Dose Vials commonly used by MTFs in BC, and gives the range of starting doses. The EV injectable comes in a thick oil. In women a normal LH level is similar to FSH. Estradiol transdermal patch Estradiol transdermal patch 50 to 100 mcg (microgram) worn weekly. Estradiol valerate 5-20mg i.m./2 weeks or cypionate 2-10mg i.m./week 4. oral 17B-estradiol oral conjugated estrogens 17B-Estradiol patch (usually replaced every three to five days) estradiol valerate injection (typically every two weeks) estradiol cypionate injection (every one to two weeks) Endocrine Society guidelines specifically suggest that oral ethinyl estradiol should not be used in transfeminine people. I inject 0.20 ml of the same estradiol valerate solution as you (20 mg/ml). My last blood test showed my estradiol at about 470 pg/mL. Patches or implants are preferred for transwomen over 40 years of age (although they can be used in younger people) to minimise the risk of venous thromboembolism. I use Estreva gel, 6 doses each day (0.5mg estradiol / dose). WARNINGS See BOXED WARNINGS. Active deep vein thrombosis, pulmonary embolism or a history of these conditions. Transdermal estrogen Estradiol patch .1-.4mg/2X week i.m., Intramuscular; MTF, male to female. 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