UNLOCK: Unlock this item by beating Greed Mode with The Lost. UNLOCK: Unlock this item by destroying 100 tinted rocks. UNLOCK: Unlock this item by beating the Chest with Blue Baby. A card with three uses: A full heal, deals 100 damage to all enemies in the current room and reveals the entire map for the current floor (Treasure Map + The Compass). The light faces the direction that you are facing, not the direction you are firing. UNLOCK: Unlock this item by beating the Boss Rush with Isaac. At the start of each new hostile room you spawn a green attack fly, which will target a nearby enemy, deal double your tear damage and then poison them. Tear damage starts at double (+100%) and decreases over range to roughly (+30%). UNLOCK: Unlock this item by beating one of the horsemen bosses for the first time. Deals 40 damage to everything in the room when used. Enemies will sometimes target the Mulligan if he is closer. * item room, treasure room, item room pool, baby, fetus, foetus, jar, white, pink, bug, dr fetus. Adds several instances of The Bible item into all item pools. You can spam the fire button to rapid fire, however the overall damage per second will be low. The effect triggers again 30 seconds after use and again 60 seconds after use, Something's wrong - Spawns a pool of black creep beneath Isaac, Vurp! * item room, treasure room, item room pool, brown, glass, beaker, white, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, The Walnut has a chance to break when taking damage from an explosion. UNLOCK: Unlock this item by picking up any 3 of these items in a single run: 9 Volt, The Battery, Car Battery, AAA Battery, Watch Battery. purple, pink, mask, face. white, red, pink. While held there is a small chance when using a tarot card or pill that a copy of it will be dropped on the floor next to you. Level 2: Bumbo gains a body and crawls around the room, sometimes dropping random pickups. It stops moving while Isaac is firing tears and upon releasing the fire button, King Baby will teleport back to your location. When the pool is empty, it will eventually re-roll all your items into heart containers. Turns your tears into bones, which shatter into 1-3 smaller bone shards upon hitting any object or enemy. yellow, white, triangle. This item is called Steamy Sale on PS4, PS Vita, Xbox One and Switch versions, probably due to copyright reasons. pink, red, eye, glow. It will also sometimes randomly drop bombs. When used with Mom's Knife, you can still deal contact damage but will be unable to change the way the knife faces while the effect is active. A familiar that follows Isaac and leaves blood creep on the floor as it floats, hurting enemies that walk over it for 2 damage per tick. The bomb explosion deals your tear damage + 60. The fire rate increase is applied in such a way that the higher your tear stat is, the more effective Cancer is. Gives Isaac a large white halo around him, that deals a bit of damage to any enemies in contact with the ring. You have to keep the fire button held down for the full 3 seconds to cause this effect. chalice, indiana jones, * angel room pool, god room pool, angel room item, bird, white. * item room, treasure room, item room pool, dollar, red, grey, gray. The chance to gain a shield is affected by your luck stat and at +27 Luck it will activate every time. Teleports the player to the Boss room on the current floor. Item Pool: None (Blood Donation machine only). poop, pots, TNT, red poop, stone blocks etc.). After the first drop, he has a 67% chance to drop a pickup after 3 coins and a 33% chance to drop a pickup after 4 coins. Item Pool: Item Room, Boss Room, Gluttony Miniboss, * boss room pool, boss room item, item room, treasure room, item room pool, red heart, ballchinnian, ball sack, full heal, gluttony, the lost item pool, * secret room pool, the lost item pool, brown, poop, turd, * secret room pool, silver, grey, gray, skull. 5c pickups become 3c. When used, has a 50% chance to drop one random type of coin (penny, nickel or dime). Higher chance to get a random drop after clearing a room. Synergises very well with invulnerability items such as Book of Shadows. UNLOCK: Unlock this item by beating Mom's heart 2 times. UNLOCK: Unlock this item by beating Boss Rush with Blue Baby. The flame destroys enemy shots, making it useful for bullet hell bosses. UNLOCK: Unlock this card by beating Challenge #3 (Head Trauma). A familiar chest that follows Isaac and has a 25% chance to drop a pickup after clearing a room. If used in the Boss Rush, all the duplicates can be taken for free as well as one of the original items. The laser ring does damage equal to your normal tears rapidly to any enemies inside the ring. Will also synergize with some other items, such as Mom's Eye, Brimstone, Dr. Fetus, Tech X or Loki's Horns, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Kieran and Stewartisme, Allows you to rapidly place bombs on the ground, Added as part of the Afterbirth+ Booster Pack #1. Tears become flat and disc shaped giving them a larger hitbox. This mechanic is very useful on Greed and Greedier modes. Synergizes very well with a lot of items. Gives the player an invulnerability effect which lasts for a 10 seconds. The accuracy of your tears is also reduced as your fire rate increases. UNLOCK: Unlock this item by beating Boss Rush with The Lost. Dying in a sacrifice room while holding this trinket will reveal a puzzle piece on the death screen. UNLOCK: Unlock this item by defeating Greedier mode with Maggy. * item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, Depths 1: 4 Soul hearts. * , the lost item pool, grey, gray, makeup. An item only found in the Boss Room pool. Items which cost 2 heart containers in a deal with the devil are reduced to only cost 1 heart. Effectively increases your range due to the tear pattern. 3c pickups become 2c. Each of the tears in the cluster deals double damage, When entering a room connected to a Secret Room or Super Secret Room, a howling sound will play, When entering a room with a crawl space trapdoor in it, a barking sound will play. Increases the chance for Black hearts to spawn. *, red, grey, gray, brown, black, red, eyes. Each subsequent kill will stack further damage up to a maximum of +5 Damage Up after 10 kills. Re-entering a room allows this effect to be triggered again. Attack Fly, Dart Fly, Eternal Fly, and Ring Fly are transformed into a neutral black fly. item when picked up again. Changes all card and rune drops into pills. Isaac will also be immune to other sources such as Mom's leg stomp, Satan's leg stomp. Using the Broken Shovel will stop Mom stomping you for the rest of the current room (or current wave if you're in the boss rush or challenge room). The highest damage orbital in the game, dealing 225 damage per second. UNLOCK: Unlock this item by entering every Shop from the first floor up to Mom's Foot (Depths 2). Contrary to popular belief, the Bible Tract doesn't allow Angel Rooms to appear after paying for a Devil Deal. Also summons a blue crosshair which can be moved around freely. Tears gain a damage up and increase in size based on the distance they travel. This item turns all doors that require a key into doors which need a coin to enter instead. UNLOCK: Unlock this item by beating the Dark Room with Eve. Isaac's health is set to 1 and he also gains 9 extra lives. When you die with this item, you respawn in the same room with 1 heart and the Anemic item. Happens a total of 3 times over 30 seconds, ??? Contact damage is also dealt to enemies equal to the amount of coins Isaac is currently holding. Also opens the boss rush door after Mom's Foot, blue womb door after Mom's Heart, secret rooms and super secret rooms, Like all single-use items, this item cannot be absorbed and used multiple times by the Void item, Entering a room with an angel statue will destroy it and automatically spawn one of the Angel mini bosses. * item room, treasure room, item room pool, sad, baby, lumpy, brown, pink. Spawns 3 red hearts on the ground when picked up. UNLOCK: Unlock this item by beating Satan with Lazarus. The angel will attract bullets towards it and block them. Based on the Steam Workshop mod created by Ink Tears. Spawns a trapdoor at Isaac's feet which allows him to travel to the next floor. Gives the player the Whore of Babylon effect for the current room, increasing damage and speed. UNLOCK: Unlock this trinket by defeating Ultra Greed as The Forgotten. Mom's Purse). UNLOCK: Unlock this item by playing the Blood Donation machine 30 times. purple, pink, circle. Cannot spawn a trapdoor directly infront of a secret room entrance. When used, removes one heart container and gives you 3 soul hearts. * item room, treasure room, item room pool, fire, heart, orange, burning, stannis. Moving to a new floor decreases the size of the hairball. *, white, grey, gray, pill, medicine, drug. A familiar which follows Isaac and spawns a white poop when you take damage, The white poop gives an aura that cuts your tear delay in half (Tears up) and has a chance to block damage, The aura disappears if the poop is destroyed. Has a chance to drop from the Gluttony miniboss fight. Heals you for 1 red heart when picked up. When used, this item will sacrifice up to 2 of your familiars (chosen at random), and spawn a random Devil Room item for each familar sacrificed this way. If you have no pickups on the ground in the current room and no other flies or spiders, Compost will spawn 1 blue fly or blue spider. Dice Shard counts as a card and will be converted. The chance to damage enemies is affected by your luck stat and at +50 or more Luck it will activate 50% of the time. * item room, treasure room, item room pool, red, wire, white, eye. UNLOCK: Unlock this item by collecting both Key Pieces #1 & #2 for the first time. It can spawn familiars you haven't unlocked yet! * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, * item room, treasure room, item room pool, the lost item pool, purple, blue, heart, cute spiderbaby. This item doesn not affect troll bombs - they will still explode. UNLOCK: Unlock this item by beating Mom's Heart 7 times. This effect stacks with multiple shades, scaling the contact damage each time. The spear occasionally inflicts fear on enemies it damages.. UNLOCK: Unlock this item by beating Blue Womb (Hush) with Maggy. For the Lost and Keeper characters, this item simply gives a permanent Tears Up. Randomly Isaac will gain a camouflage for a few seconds and all enemies in the current room will have a confused status effect applied to them. If you get hit in either of the other 2 states you will not be teleported. UNLOCK: Unlock this item by sleeping in 10 different beds. Taking an eternal heart to the next floor or collecting two on the same floor gives you an extra heart container. After picking up 15 hearts, Isaac gains a permanent angelic familiar and a soul heart drops. Stats effected by this item are: Damage, Tears, Range, Speed. Tear effects include: Anti-Gravity, GodHead, Proptosis, Tiny Planet, Holy Light, Soy Milk, Cricket's Body, Explosivo, Continuum, My Reflection, Ring Worm, Hook Worm, Wiggle Worm, Flat Worm. The finger deals 10% of your normal damage to all enemies in the same direction that the finger is pointing. Plan C is 5 times rarer than other items in the same item pool, making it less likely to appear. Has a chance to drop from the Pride miniboss fight. When used, turns all pickups and chests in the room into Coins. The daze effect is effectively permanent for normal enemies, and has a much longer duration for bosses compared to other status effects. blue, white, triangle. Can destroy rocks if used when Isaac is flying over a rock. * angel room pool, god room pool, angel room item, shop room pool, shop item pool, Spawns guppy flies if you have the Guppy transformation. This can be used multiple times in the same room to generate more familiars, meaning you can get a level 4 meatboy or bandage girl by using this item 3 times in the same room. Luck-based items such as Holy Light are applied to each tear individually. Black Judas is considered a separate character by the game, however he can be used to unlock Judas' secrets/achievements. 15c items are reduced to 7c. * item room, treasure room, item room pool, book, brown, blue, monster manuel, manaul. *, mr me!, Mr Meeseeks, rick and morty, brown, chest, szechuan sauce, Grants a prism orbital with a large orbital radius, Isaac's tears that pass through the prism split into four multi-colored tears, Does not deal contact damage to enemies that it passes over, Added as part of the Afterbirth+ Booster Pack #3. As you hold down the fire button, shots will float in the same place until you release the fire key again. Will hurt Isaac if he is in the blast radius. Allows Isaac to fly while the White Pony is held. An iron ball and chain attached to Isaac, similar to Guppy's Hairball that you can fling around to deal 5 damage per tick. UNLOCK: Unlock this item by beating Satan with Lilith. achievement (collect 50 items in a single run), X-Lax - Spawns a pool of slippery brown creep beneath Isaac, The same order as the in-game collection page. The shield will rotate based on the direction in which Isaac is firing tears. *, grey, gray, silver, lump, metal, stone. A Loki familiar that follows Isaac and shoots tears 4 tears in a cross pattern, dealing a flat 3.5 damage each. * item room, treasure room, item room pool, the lost item pool, pink, purple, candy. A familiar that follows Isaac and charges forwards very slowly, dealing 2.7 damage per tick to any enemies it comes into contact with. * angel room pool, god room pool, angel room item, red, fire, flame, orange, cross. red, pink, broken. A familiar which follows Isaac and, upon taking damage, will spawn a charmed enemy that will fight for you, When the charmed enemy is spawned the egg will crack, but regenerate in the next room. When the tears are released, they will fire off in the direction that Isaac was originally facing when it was created. Sheol: 1 Devil Room Item + 1 Black Heart. A familiar that follows Isaac and charges forwards, dealing 3.5 damage per tick to any enemies it comes into contact with. After all 5 familiars have spawned, it will just drop a soul heart every 15 hearts collected. Isaac gains a cloud familiar that follows him and leaves a trail of tears on the floor which damages enemies for 2 damage per tick. Can only happen once per room. * Item Room, Greed Mode Item Room, dunce cap, white, hat, cone. See the Broken Shovel / Mom's Shovel items for more information on how to unlock. Gives huge horns which stick out, allowing you to deal 18 contact damage if you hit something with enough speed. A familiar angel which follows Isaac and fires Sacred Heart tears which deal 10 damage at -25% shot speed and a reduced fire rate. * item room, treasure room, item room pool, pink, purple, red, broken. Stat Down becomes Stat Up, 'Bad Trip' turns into 'Balls of Steel' and 'Amnesia' turns into 'I can see forever'. It also doesn't do poison damage despite having the tagline 'toxic aura tears'. Counts as 1 of 3 cat items needed towards the Guppy transformation. UNLOCK: Unlock this item by beating Boss Rush with Eve. Does not count as one of your three standard orbital slots. 4 cubes of meat cause the meat boy familiar to grow in size and do 5.5 damage per tick instead. A crown that replaces normal tears with blue diamond tears while you don't have any empty red heart containers or bone hearts. Black Candle removes the teleportation effect of Cursed Eye. Blood donation machines and devil beggars can be used for free. In Afterbirth+ this card does not work on the Delirium boss. This item appears in the Devil Room but is weighted to be about 5 times rarer than all other devil room items. Has a chance to drop when exploding a tinted rock. Some hard coded spacebar items from bosses and mini-bosses (i.e. Tears Down significantly (tears = tears * 2.1 + 3). * item room, treasure room, item room pool, blue fly, big fly, blue baby's only friend, fat, dead, ?? Essentially a one-time use of the Epic Fetus item. The chance to concuss enemies is affected by your luck stat and at +27 Luck it will activate every time. Rainbow Baby's tears can choose from any of the other familiars, such as homing, spectral, tar shots etc. Allows you to reflect projectiles away from Isaac (Afterbirth only feature). Poop in the environment will now explode when destroyed. Similar to Explosive Diarrhea but with poop, Retro Vision - Pixelates the screen for a few seconds, obscuring your vision. Cannot be used to escape the Mom's Foot boss, open angel/devil rooms, or open the door to the Blue Womb floor. UNLOCK: Unlock this item by beating Challenge #13 (Beans!). The invincibility effect is shown via a rapid flashing animation. Does not prevent Isaac from taking contact damage. UNLOCK: Unlock this item by having two items or effects that grant homing shots at once (e.g. Gives Isaac a laser that will fire at random intervals in addition to your normal tears. The chance to slow enemies can improve based on your luck stat and will always slow enemies at +18 Luck. grey, gray, pentagram. After capturing an enemy, the next use of the Friendly Ball will re-spawn the same enemy as a friendly companion which will attack other enemies. - Gives the curse of the maze effect for the current floor. in a small boss room). If a trinket has been smelted, it won't appear a second time unless the entire trinket pool is exhausted or you restart the run (e.g. UNLOCK: Unlock this item by beating Blue Womb (Hush) with Samson. Can be overridden by other tear modifiers such as Mom's Knife or Brimstone. * item room, treasure room, item room poolgrey, gray. Leaves a pool of green creep under all bombs you place, which damages enemies that walk over it. Gives you a Tonsil familiar, which follows Isaac and blocks enemy projectiles. A familiar that will follow Isaac and copy the effect of one of your other familiars. One of the following messages may show: "Some doors require a blessing. at base damage of 3.5, that's 45 damage). - When used will consume your current trinket, destroying it and giving you its effect permanently. shop item pool, x, paper. treasure room, item room pool, yellow, golden, ring, circle, Item Pool: Item Room, Shop, Challenge Room, Beggar, Demon Beggar, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, item room, treasure room, item room pool, yellow, red, blue, medicine, jar, drug. * item room, treasure room, item room pool, heart, smile. * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, axe, silver, When picked up, drops between 1-6 random pickups on the floor. UNLOCK: Unlock this item by beating the Boss Rush with Azazel. Can be used in a shop to duplicate pickups which have not yet been purchased, and take the duplicate pickup for free. Upon use, the Smelter will destroy your currently held trinket and give you the effect permanently, allowing you to stack up lots of different trinket effects. Reveals the locations of the secret and super secret room for the current floor and all future floors. * red chest pool, red chest item pool, shop room pool, shop item pool, blue box. Also has a 25% chance to spawn another Blank Rune upon use. - Destroys all poops in the room and spawns a blue attack spider on every destroyed poop, Infested? pink, purple. Gives Isaac invincibility and +0.28 Speed for 6 seconds. * mom's foot, mom fight, mom boss, dark room, photo, family, kodak, inverted. If there are no enemies this pill spawns 1-3 blue spiders instead, One makes you smaller - Reduces Isaac's size and hitbox size, One makes you larger - Increases Isaac's size, but does not affect the size of his hitbox, Percs - Causes Isaac to only take half a heart of damage from all sources for the current room (The Wafer effect). Counts as 1 of 3 familiar items needed towards the Conjoined transformation. Every type of heart will be affected (except for hearts spawned in Super Secret Rooms) and causes Mitre, Bible Tract, Mom's Pearl to become useless. Compatible with bomb modifiers, such as Glitter Bombs, Sticky Bombs etc. UNLOCK: Unlock this item by beating the Depths 20 times and killing the Gish boss. pills in one run. After hitting its first enemy, each tear will double in damage and gain a homing effect. Items and trinkets which generate blue flies and spiders will have double the effect, causing twice as many to spawn, *, grey, gray, green, arrow, flower, plant, Some tears will randomly become a black tooth, that deal double your normal tear damage and can poison enemies, Tears become spectral and travel in a large spiral pattern, Every time you take damage you have a very small chance to gain a Tonsil familiar, which follows you and blocks enemy projectiles, This effect can happen twice before the Tonsil trinket is destroyed. The chance to create a spider is affected by your luck stat and at +10 Luck it will activate every time. * item room, treasure room, item room pool, glass, blue, water. Gives you a familiar demon incubus that follows you and shoots tears exactly the same as Isaac's in terms of damage, stats and also effects. Clouds last 15 seconds before disappearing. UNLOCK: Unlock this item by defeating Greedier Mode with Judas. Transforms Isaac's tears into a wide arc shape which doubles their size and hitbox. Each time you get hit, you drop a coin or two. If used in a normal room with enemies it will teleport you out and back into the exact same room. This item only costs 1/2 a heart to use if you have The Wafer item. This item is a reference to Spider853, creator of Spidermod for the original game and one of the lead developers that worked on Rebirth and its DLCs. Each time you enter a new room, damage is negated for the first time you get hit. Causes your familiars to stay closer to each other. This item also turns your tears red, but does not change your actual damage stat or the damage your normal tears do, The chance to fire a razor blade depends on your luck stat, and at +14 luck you will fire a razor blade every time, With every 15 tears fired, Isaac will fire a cluster of 12 tears instead of your normal tear. * boss room pool, boss room item, eight, grey, gray. If used in a shop and the effect fails, a Restock box can be used to restore the shop items. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). A second Pentagram will give an extra +5% chance. * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, bloody, UNLOCK: Unlock this trinket by defeating Greedier Mode with Samson. Your damage stat is unaffected by this item, however the large bloody tear does +31% of your tear damage and the smaller scattering tears deal 50-80% of your tear damage. The floating Dead Cat head that follows you will disappear when you are on your last life (Very useful for The Lost). When used, this item will rewind time and put you back in the previous room, in the same state you were in at that moment. The chance to fire a Holy tear is affected by your luck stat, maxing out at a 50% chance. When you take damage, there is a 50% chance to drop a random heart, key, bomb or coin. Isaac flashes blue very briefly when damage is negated by this item. * item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, Cannot lower the charge of your spacebar item below 1 room. Killing the marked enemy will cause the skull to move to a different enemy. Gives you another secret room on each new floor while held, Does not spawn more than one super secret room, only the normal secret room, *, purple, torn, ripped, paper, page, poster, When you have the same amount of coins, bombs and keys, half consumables turn into their doubled version, This effect works for any number of consumables, including 0 and 99, as long as the count for coins/keys/bombs is equal, Every time you take damage you have a very small chance to spawn a random pedestal item, When the effect triggers, the trinket is destroyed, Every time you take damage you have a very small chance to spawn the Lunch item, which gives +1 HP up, When the effect triggers, this trinket is destroyed, Increases the radius of any creep you produce, While held, any damage taken will ignore soul hearts and black hearts, causing your red heart containers to be depleted first. * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, * shop room pool, shop item pool, the lost item pool, white. Also rerolls all your stats at the same time, giving a random flat modifier that changes each time. Enemies killed with the black ring have a 5% chance to drop Black hearts.