As this study was not performed in Zn-deficient animals, it provides evidence that Zn is probably effective in the absence of Zn deficiency. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. The therapeutic and prophylactic efficacy of 5% lactic acid mouth wash, 5% zinc sulphate oil in the management of RAU. For the determination of the statistical significance among different variables, descriptive statistics like mean and standard deviation were used together with analytic statistics like Chi-square, using EPI version 6. Improve clinical decision support with information on. In group I, the mean reduction in PASI score was 39.1% at 4 weeks from the mean base line PASI score, meanwhile the reduction in PASI score at 8 and 12 weeks were 58% and 62.3% respectively. C Poor response was noticed in three (6.9%) patients. Patients were divided into three groups; patients in group I were treated with zinc sulphate cream 2.5%, while group II patients were treated with clobetasol propionate cream 0.05% and patients in group III were treated with zinc sulphate2.5% plus clobetasol propionate cream. On the contrary, its topical application has shown improvement at experimental and clinical level in patients presenting with both deficit and normal serum levels. Zinc Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for TPN. They were 65 (49.6%) females and 66(50.4%) males, with female: male ratio 1:1.1. It can be recommended for use in clinical routine and trials. FOIA Zinc facilitates wound healing, helps maintain normal growth rates, normal skin hydration and the senses of taste and smell. Topical therapy of acne vulgaris using 2% tea lotion in comparison with 5% zinc sulphate solution. Zinc has been used successfully in the treatment of many skin diseases such as Cutaneons leishmaniasis( 7,8, 9)and Viral warts(10,11), where it was found to be safe, noncostly and effective therapy. B Patients who achieved partial response with a reduction in PASI score ranged from 25-49% were 13 (28.9%). Sharquie KE, Al-Mashhadani SA, Noaimi AA, Hayani RK, Subber SA. Formal consent was taken before the start the therapy, after full explanation about the nature of the disease, course, the procedure of treatment, follow up, prognosis and the need for pre and post treatment photographs. The advantages over zinc sulphate, which is a water-soluble compound, are due to the fact that it enables a sustained release of zinc avoiding cytotoxic levels. The relapse rate was (75%) cases. Partial response cases with PASI score reduction 25-49%, C. Poor response cases with PASI score reduction <25%. Zinc deficiency, due to either hereditary or dietary causes, has been associated with skin alterations and delayed healing. Separate the use of zinc from these products by at least 2 hours before administration. Treatment of psoriasis with zinc sulphate cream 2.5% in comparison with clobetasol propionate cream. It is also one of the most important factors in a healthy immune system. This is a single-blind therapeutic trial conducted in the Department of Dermatology and Venereology, Baghdad Teaching Hospital during December 2006 to September 2008. The main purpose of this observational study was to conduct a cost-utility analysis (CUA) and a cost-effectiveness analysis (CEA) comparing punch grafting (n = 46) with usual care (n = 34) for the treatment of chronic wounds in an outpatient specialized wound []. Defaulted rate: Twenty two cases (16.8%) were defaulted from the treatment. Epidermal and appendageal tumours. It presents as a skin-colored to reddish-brown or yellowish-black, well defined macule, papule or plaque varying from pinhead sized to several centimeters in diameter. This is a single blind comparative, therapeutic, out patient based study where 131 patients with mild-moderate psoriasis, consulting the Department of Dermatology and Venereology in Al Sadder teaching hospital in Basrah during the period from Dec. 2004 through Aug.2006, were enrolled in this study. A Thirty two (74.4%) patients showed a good response with a reduction in PASI score 50%. privacy practices. Portions of this document last updated: July 01, 2022. Eur J Vasc Endovasc Surg. information submitted for this request. This product is available in the following dosage forms: There is a problem with Diagnosis was clinical and confirmed by histopathological examination especially in patients with suspected lesions.Lesional biopsies from five treated patients were taken after stopping therapy for histopathological assessment. All the following conditions were excluded from this work: Lesions with erosion, oozing or crustation, size more than 1.5 cm in diameter unless proved by biopsy to be AK, the presence of regional lymphadenopathy. Consultant dermatology, Head, Department of Dermatology and Venereology, Basrah Medical College. Sharquie KE, Al-Mashhadani SA, Hayani RK, Al-Noaimi AA, Subber SA. Understanding the principles that underlie compression therapy is essential for success. Department of Dermatology and Venereology, College of Medicine, Baghdad University, Laith C. Al-Kinani, MBChB Group I: Included patients who were treated with zinc sulphate cream 2.5%. They were 65 (49.61%) females and 66 (50.4%) males, with female: male ratio 1:1.1. Their ages ranged from 6-65 years with a mean of 27.4 17 years. Comparative clinical trial of topical 10% zinc sulphate solution for treatment of melasma. Fitzpatrick's Dermatology in General Medicine. This medicine is available as an over-the-counter (OTC) product. Considering leg wounds, a randomized clinical trial with 113 patients with venous ulcers compares 3 treatment arms: zinc paste bandage, zinc stockings and a calcium alginate dressing.4 In all cases a highly elastic bandage was also used. While skin photo types were 5 (27.77%) patients type II and 13 (72.23%) patients with type III-IV. Stacey MC, Jopp-Mckay AG, Rashid P, Hoskin SE, Thompson PJ. Zinc has been described in many literatures as an effective treatment for many dermatological diseases so that zinc sulphate is used in this study as a topical treatment of psoriasis. UBM Medica Network Privacy Policy, Use your account on the social network Facebook, to create a profile on BusinessPress, Table 2: showing the degree of response in different modalities of treatments, Table 3: Showing relapse rate for different modalities of treatments, Treatment of psoriasis with zinc sulphate cream 2.5% in comparison with clobetasol propionate cream. The difference in the degree of improvement in the three groups at 12 weeks of treatment were statistically significant with P. value <0.05%)%) but it is clearly seen that topical treatment with a combination of zinc sulphate 2.5% and clobetasol propionate cream 0.05% induced the best results and with relatively shorter period of time. Topical zinc sulphate solution for treatment of viral warts. and transmitted securely. Objectives: To evaluate the effectiveness of topical zinc sulphate cream 2.5% in treatment of psoriasis, in comparison with clobetasol propionate cream 0.05% alone and zinc sulphate 2.5% plus clobetasol propionate 0.05% cream . [16], Chronic ultra violet light exposure is considered to be the most important factor in the development of actinic keratosis. Mayo Clinic does not endorse companies or products. Reactive oxygen species have been implicated in the pathogenesis of various hyperproliferative and inflammatory disease. Warnings: Store in a cool dry place and tightly capped.Keep out of the reach of children.Discontinue use if skin becomes irritated. Zinc is 60% bound to albumin; 30 to 40% bound to alpha-2 macroglobulin or transferrin; and 1% bound to amino acids, primarily histidine and cysteine. Mild burning sensation at the treated site is the only side effect of zinc sulphate which was reported in 26.1% of the cases. In addition, it has also been shown that topical zinc in wounds promotes autolytic debridement. Kadhim KA. Zinc inhibits cAMP-induced, chloride-dependent fluid secretion by inhibiting basolateral potassium (K) channels, in in-vitro studies with rat ileum. Most patients were in the second and third decades of life. It can also be performed on an outpatient basis. In group II the mean reduction in PASI score was 51.2% from the mean base line PASI ( 8.6 5.5 ) at 4 weeks , while the reduction in PASI score at 8 week and 12 weeks were 60.5% and 62.8% respectively. It is primarily stored in RBCs, WBCs, muscles, bones, Skin, Kidneys, Liver, Pancreas, retina, and prostate. Itching was reported in about 89.3% of patients. CONCLUSION: Punch grafting is a simple, validated and cost-effective technique that can be performed on an outpatient basis, promotes wound healing and reduces pain. After absorption zinc is bound to protein metallothionein in the intestines. Response to treatment was determined by the following criteria: Number, size, erythema, roughness, and scaleness of lesions. The combination of zinc sulphate plus clobetasol propionate proved to be better than clobetasol propionate and zinc sulphate alone as it induced marked and complete remission of psoriasis in about 83.7% of cases. The role of zinc in wound healing has been studied predominantly in experimental animal studies. HHS Vulnerability Disclosure, Help information and will only use or disclose that information as set forth in our notice of 4- It is also well known that a deficiency of zinc produce a disease state (Acrodermatitis enteropathica) that include Psoriasiform lesion (26, 27). Therefore, well- designed clinical trials are needed to analyse the real clinical utility of topical zinc in patients with leg ulcers. Advertising revenue supports our not-for-profit mission. Punch grafting, which may be performed in an outpatient setting, is well tolerated by patients and may be repeated several times if necessary. Assistant Prof. Khalil I Al-Hamdi MD PhD, The head of Department of Dermatology and Venereology, Basrah medical college. On the other hand, psoriasis in those patients treated with a combination of zinc sulphate and clobetasol propionate relapsed in 77.8%. Associated predisposing medical conditions such as renal transplant, xeroderma pigmentosa, epidermodysplasia verruciformis were also excluded. If normal levels exist, the conclusion of a systemic review of six clinical trials including leg wounds (with small sample size and different limitations) is that there is no benefit over placebo.3. This topical cream contains zinc sulfate. Save my name, email, and website in this browser for the next time I comment. Unfortunately, to the best of our knowledge, no previous studies about the same subject have been done to compare our results with. In spite of advances represented by biologics, topical treatment will probably remain the mainstay of psoriasis therapy for most patients (4) but; unfortunately there is no unique curative systemic or topical treatment for the disease. Utilizamos cookies para asegurar que damos la mejor experiencia al usuario en nuestro sitio web. Criteria for response to therapy with 25% topical zinc sulphate solution in patients with actinic keratosis. The number of lesions for each case was less than 10 AKs in 4 (22.22%) patients, between 10-40 AKs in 10 (55.56%), and more than 40 AKs in 4 (22.22%) patients, thus 100 lesions of actinic keratosis were treated. Zinc sulphate treatment restores both the random migration and directed chemo taxis to normal values (zinc sulphate modifies neutrophil inflammatory potential) (16). On the basis of the above mentioned results it is clearly seen that topical treatment with a combination of zinc sulphate 2.5% and clobetasol propionate cream 0.05% induced the best results and with relatively shorter period of time . They were 43 patients; 21 (48.8%) females and 22 (51.2%) males. Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". In: Freedberg IM, Eison AZ, Wolff K, Austenk F, Goldsmith LA, Katz SI, editors. The response to treatment in different groups (Table 1, 2): The patients were subdivided into three groups according to their response to treatments as follow: A Patients who achieved a good response with a reduction in PASI score 50% were 24 (53.3%). The site is secure. 1997 Feb;13(2):174-9. This result is in contrast to that mentioned in literature where the scalp and the extremities are considered as resistant sites to other modalities (1). Easily compare up to 40 drugs with our drug interaction checker. There was no difference in response between 10 and 12 weeks of treatment. The patients were divided into three groups according to their topical treatments, as follows:-. Sharquie KE, Khorsheed AA, Al-Nuaimy AA. Skin photo-type was established for all patients according to Fitzpatrick's classification and any signs of sun damage were recorded. Recent reports found that serum zinc is lower in psoriatic patients in comparison with non psoriatic ones (17, 18). Gluten and casein free. The relapse rate was (78%) cases. Khalil I. Al-Hamdi, M.D., Ph.D. The lesion usually has a hyperkeratotic surface that is often better recognized by palpation, as a roughening, rather than visualization.